CAS 77-78-1 · Di Methyl Sulfate

Di Methyl Sulfate: direct from source to Europe

Di Methyl Sulfate (CAS 77-78-1) is a colourless oily liquid and powerful methylating agent used in the manufacture of pharmaceuticals, agrochemicals, dyes, quaternary ammonium compounds and fine chemicals.

  • COA, SDS & TDS with every batch
  • REACH status confirmed before quote
  • Samples available for qualification
Purityup to 99.5%+GC assay, premium grade
Lead time3 – 6 weeksOrigin to European port
FormLiquidDrums to ISO tank
Response1 business dayQuotation after receiving your spec
Product identification

Di Methyl Sulfate: names, synonyms and identifiers

Buyers search for this material under several names. Whichever one appears on your specification, purchase order or REACH dossier, it is the same compound: Di Methyl Sulfate, CAS 77-78-1.

  • Confirmed CAS number on every COA
  • Premium grade with GC assay 99.5%+ available
  • TDS and SDS supplied with every shipment
Common name
Di Methyl Sulfate
Synonyms
DMS · Dimethyl sulphate · Sulfuric acid dimethyl ester
CAS number
77-78-1
Formula / MW
C2H6O4S  /  126.13 g/mol
Chemical family
Alkyl sulfate (methylating agent)
HS code
2920 (esters of other inorganic acids). Confirm the full code with your broker.

⚠ Toxic and carcinogenic. Supplied to verified professional industrial users only. Always match CAS 77-78-1.

Technical data

Di Methyl Sulfate physical and chemical properties

Key parameters for process engineering, safety planning and storage design. Values are typical; always verify against the current TDS for your lot.

Appearance
Colourless oily liquid
Faint onion-like odour
Melting point
Approx. −32 °C
Typical value
Boiling point
Approx. 188 °C
Decomposes on heating
Molecular weight
126.13
g/mol
Molecular formula
C2H6O4S
Alkyl sulfate ester
Solubility
Reacts slowly with water
Hydrolyses to methanol and sulfuric acid
Density
1.33 g/cm³
At 20 °C
Storage
Cool & dry
Closed container, away from water and bases
Quality & specification

Di Methyl Sulfate grade specifications: standard vs premium

Two grades are offered so your process chemist or quality team can pick what suits downstream requirements. COA parameters are confirmed before every shipment.

Parameter
Standard grade
Premium grade
Test method / note
GC assay
≥ 99.0%
≥ 99.5%
GC area %
Acidity (as H₂SO₄)
≤ 0.10%
≤ 0.05%
Titration
Water content (KF)
≤ 0.05%
≤ 0.02%
Karl Fischer titration
Identity
Confirmed
Confirmed
GC or IR
Appearance
Colourless clear liquid
Colourless clear liquid
Visual check

All values are specification limits, not guaranteed minima. Actual COA figures for your lot are provided before dispatch. Non-standard specifications are available on enquiry.

Applications

Where Di Methyl Sulfate is used

Typical end uses and synthesis routes for European manufacturers, toll processors and laboratories.

Methylation reagent

O-, N- and S-methylation in pharmaceutical and agrochemical synthesis.

Quaternary ammonium compounds

Quaternisation of tertiary amines for surfactants and specialty salts.

Dyes and fine chemicals

Methyl ethers, esters and methylated intermediates.

Custom synthesis

Reagent for contract synthesis at industrial scale.

Packaging & logistics

Packed to your site, documented for customs

Di Methyl Sulfate is handled as a dangerous good. Every shipment leaves with UN-approved packaging, CLP labelling and the full document set for European import.

Drums

Steel drums

UN-approved steel drums with secure closures, palletised.

Up to 250 kg net
IBC

IBC / ISO tank

UN-approved IBCs or ISO tank containers for higher-volume users.

On request
Bulk

Bulk supply

Bulk supply packed to agreement for suitable receiving sites.

On request
Document set included: Bill of lading · Commercial invoice · Packing list · Certificate of analysis (COA) · Safety data sheet (SDS) · Dangerous goods declaration (IMDG/ADR) · Certificate of origin · Other certificates on request
Common questions

Di Methyl Sulfate: frequently asked questions

Quick answers for European buyers. For anything else, email source@cheloragroup.com.

It is also sold as DMS, Dimethyl sulphate, Sulfuric acid dimethyl ester. All refer to CAS 77-78-1. Confirm the CAS number with any supplier before ordering.

Price depends on grade, volume, packing, Incoterm and destination port, and moves with raw material markets. Send us your requirement and we will quote in EUR or USD with a landed-cost breakdown, usually within one business day.

Di Methyl Sulfate (CAS 77-78-1) is a colourless oily liquid and powerful methylating agent used in the manufacture of pharmaceuticals, agrochemicals, dyes, quaternary ammonium compounds and fine chemicals.

Standard grade offers 99.0% minimum GC assay. Premium grade offers 99.5% minimum with lower acidity and water content, and is recommended for moisture-sensitive methylations with tight impurity control.

Dimethyl sulfate is a strong, cost-effective methylating agent. Dimethyl carbonate is much milder and less hazardous, while methyl iodide is more expensive and volatile. The right choice depends on reactivity, cost and your site safety controls.

Di Methyl Sulfate is classified as toxic and carcinogenic under CLP and is supplied only to verified professional industrial users with appropriate handling controls. We confirm REACH and CLP status, and any authorisation or notification duties, for your application before quoting.

Store in closed, corrosion-resistant containers in a cool, ventilated, access-controlled area, away from water, bases, amines and oxidisers. Use within the shelf life stated on the COA and TDS.

It is a toxic and corrosive dangerous good (Class 6.1, UN 1595; always confirm on the current SDS). We pack it in UN-approved containers, apply CLP labels and ship through licensed forwarders under IMDG for sea and ADR for European road.

Yes. Laboratory and pilot samples are supplied with a COA and SDS so your team can qualify the grade. Mention sample needs in your enquiry.

REACH status is confirmed before we quote. We advise on importer-of-record arrangements and whether the substance is registered for your use. Send your use descriptor and we will confirm.

Ready to source?

Get your Di Methyl Sulfate quotation today

Send us the grade, volume, destination and Incoterm. You will receive a clear price, packaging options and a full document checklist, usually within one business day.

  • Samples to full containers
  • COA, SDS and DG documents included as standard
  • Quote in EUR or USD, your choice of Incoterm